Mugen no Juunin: Bakumatsu no Shou

The sequel is set in the Bakumatsu period in the 19th century (the original manga was set in the earlier Edo period), and follows the main character Manji, who starts the story in a life of seclusion in the Tosa domain, but heads to the capital for a certain reason. The story will have him confronting the strongest warriors of the time.
(Source: Anime News Network)