Hana Yori Dango

Tsukushi Makino is accepted into the prestigious, Eitoku Academy. Life changes dramatically for Tsukushi when her friend falls on Tsukasa Domyoji. Tsukasa is the explosive leader of the "F4," a group of the most powerful, rich and handsome boys. Domyoji refuses to accept Makiko's apology and Tsukushi steps in to protect her friend. A red tag appears in the Tsukushi's locker the next morning which is a sign from the F4 that she is to be bullied by the school. Tskushi continues to stand up to her oppressors.
(Source: VIZ Media)
Note: Includes the one-shot "End of the Century"