Tezuka Osamu no Buddha: Akai Sabaku yo! Utsukushiku

In ancient India, the lives of the re plagued by drought, famine, constant warfare and the injustices of the strict caste system. The intertwining lives of many unhappy souls are drawn together by the birth of the young prince Siddhartha, who embarks on a spiritual journey, becomes Buddha, "the Enlightened One," and attempts to bring about a spiritual rebirth of the people in this desperate age.
(Source: Anime News Network)