Ergo Proxy

Something is wrong in the perfect domed city of Romdo. Between the sudden rash of murders and a virus affecting all AutoReivs-cyborg companions and workers who assist the people of Romdo - all is not right in their dome home. Detective Re-l Meyer begins to investigate, seeking answers to the weird occurrences that are happening more and more around her. But when she begins to uncover the truth, her world is turned upside down.

First, the strange immigrant Vincent Law goes missing and then a monster appears before her, shaking her to her core. But this monster is something more, something dangerous and sinister. With each question and mystery, she is led back to the creature. But what is it really? What purpose does it serve? A sign of the end or a sign of a new beginning? Whatever it is, it repeatedly brings her back to Vincent and soon, alongside his journey back to another dome world called, Mosk. As they make their way across scarred and deserted Earth, Re-l and Vincent will learn more about the monster and the "awakening"-which could be more of an ending than a beginning.

(Source: Funimation)
Note: Episode 1 received an advanced broadcast on channel WOWOW on February 5, 2006. The start date reflects the start of the regular series broadcasting.